Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nociception01:44

Nociception

31.2K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
31.2K
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

6.6K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
6.6K
Somatosensation01:33

Somatosensation

41.0K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
41.0K
Introduction to Sensory Receptors01:31

Introduction to Sensory Receptors

6.0K
Sensory receptors are vital in our ability to perceive and interpret the world. Sensory receptors are specialized cells in the peripheral nervous system that respond to various stimuli and enable one to experience different sensations. Based on specific criteria, sensory receptors are classified into distinct types.
The first classification criterion is based on cell type, position, and function. Some receptor cells are neurons with free nerve endings, where their dendrites are embedded in the...
6.0K
Thermosensation01:43

Thermosensation

32.7K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
32.7K
Nervous Tissue: Neuron Types01:19

Nervous Tissue: Neuron Types

4.4K
Neurons, the fundamental units of the nervous system, can be classified based on both their structural and functional characteristics.
Structurally, neurons are categorized into three main types: multipolar, bipolar, and unipolar (or pseudounipolar). Multipolar neurons, which are the most common type in the brain and spinal cord, as well as all motor neurons, possess multiple dendrites and a single axon.
Bipolar neurons, on the other hand, have one primary dendrite and one axon. They are...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep Cellular and Spatial Profiling of the Mouse Spinal Cord Reveals Sex-Specific Neuron Types and the Ascending Projection Neuron Repertoire.

bioRxiv : the preprint server for biology·2026
Same author

Proprioceptive Stimuli as a Trigger for Leucine-Rich Glioma-Inactivated-1 (LGI1) IgG Associated Autoimmune Seizures, a Case Report.

The Neurohospitalist·2026
Same author

Development of the spinocerebellar system within the precerebellar network.

Current topics in developmental biology·2026
Same author

Unbiased quantification of persistent postural and motor deficits following spinal cord injury in mice.

PloS one·2026
Same author

Racial and Ethnic Disparities in Clinical Characteristics and Outcomes in Adults With Encephalitis: A Retrospective Study.

Journal of central nervous system disease·2026
Same author

The role of hypoglycorrhachia as a cerebrospinal fluid to serum glucose ratio in adults with encephalitis.

Journal of neuroimmunology·2025
Same journal

The oocytes of basal dermapterans lack the posterior pole lysosomal compartment (PPLC).

Developmental biology·2026
Same journal

A central role for Islr2 (Linx) in direct pathway striatal projection neurons for the correct formation of the internal capsule and cerebral peduncle.

Developmental biology·2026
Same journal

Shared candidate genes associated with variation in egg size in cold-adapted and artificially selected Drosophila melanogaster.

Developmental biology·2026
Same journal

The molecular mechanism underlying melatonin-mediated repair of ovarian damage in mice exposed to abnormal light cycles.

Developmental biology·2026
Same journal

The Drosophila ovarian terminal filament imports lipophilic molecules that support cyst and follicle development within the ovariole.

Developmental biology·2026
Same journal

Secreted Frizzled-Related Protein 1 Controls Distal Lung Formation via Wnt and PDGF Signaling.

Developmental biology·2026
See all related articles

Related Experiment Video

Updated: Oct 25, 2025

Adult Mouse DRG Explant and Dissociated Cell Models to Investigate Neuroplasticity and Responses to Environmental Insults Including Viral Infection
09:23

Adult Mouse DRG Explant and Dissociated Cell Models to Investigate Neuroplasticity and Responses to Environmental Insults Including Viral Infection

Published on: March 9, 2018

22.1K

Nociceptor subtypes are born continuously over DRG development.

Mark A Landy1, Megan Goyal1, Helen C Lai1

  • 1Dept. of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA.

Developmental Biology
|August 5, 2021
PubMed
Summary
This summary is machine-generated.

Sensory neuron development in mice reveals nociceptors have broader birthdates than previously thought. This study refines understanding of sensory neurogenesis timing and cell type diversity.

Keywords:
5-Ethynyl-2′-deoxyuridineBirthdatingDRGNociceptorsSensory neurogenesis

More Related Videos

Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats
12:00

Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats

Published on: September 29, 2016

14.8K
Dorsal Root Ganglia Isolation and Primary Culture to Study Neurotransmitter Release
08:15

Dorsal Root Ganglia Isolation and Primary Culture to Study Neurotransmitter Release

Published on: October 6, 2018

51.4K

Related Experiment Videos

Last Updated: Oct 25, 2025

Adult Mouse DRG Explant and Dissociated Cell Models to Investigate Neuroplasticity and Responses to Environmental Insults Including Viral Infection
09:23

Adult Mouse DRG Explant and Dissociated Cell Models to Investigate Neuroplasticity and Responses to Environmental Insults Including Viral Infection

Published on: March 9, 2018

22.1K
Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats
12:00

Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats

Published on: September 29, 2016

14.8K
Dorsal Root Ganglia Isolation and Primary Culture to Study Neurotransmitter Release
08:15

Dorsal Root Ganglia Isolation and Primary Culture to Study Neurotransmitter Release

Published on: October 6, 2018

51.4K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Sensory neurogenesis in the dorsal root ganglion (DRG) occurs in two waves: larger, myelinated neurons first, followed by smaller, unmyelinated nociceptive neurons.
  • Previous birthdating studies relied on DRG soma cell size, leaving the precise birthdates of molecular nociceptor subtypes unknown.

Purpose of the Study:

  • To determine the birthdates of distinct molecular subtypes of sensory neurons, particularly nociceptors, within the lumbar DRG of mice.
  • To investigate if nociceptor subtypes are born within distinct temporal windows or overlap significantly.

Main Methods:

  • Utilized a thymidine analog (EdU) to label newly post-mitotic neurons in developing mouse DRG.
  • Co-labeled EdU-positive cells with known sensory neuron subtype markers to identify their birthdates.
  • Analyzed birthdate distributions for various nociceptor subtypes (Aδ-fiber, peptidergic C-fibers, non-peptidergic C-fibers) and C-low-threshold mechanoreceptors (C-LTMRs).

Main Results:

  • Different nociceptor subtypes are born on similar timescales, with continuous births from embryonic day (E) 9.5 to E13.5, peaking between E10.5 and E11.5.
  • Thinly myelinated Aδ-fiber nociceptors and peptidergic C-fibers exhibit broader birthdates (E10.5-E11.5) than previously recognized.
  • Non-peptidergic C-fibers and C-LTMRs show a peak birthdate around E11.5.
  • The proportion of nociceptor subtypes born at any given timepoint is consistent across different cell type markers.

Conclusions:

  • While overall sensory neurogenesis fits the classical two-wave model (E10.5 for touch/proprioceptive fibers), nociceptors display a broader and more continuous wave of birthdates.
  • Nociceptor subtypes differentiate throughout sensory neurogenesis, irrespective of myelination status.
  • Intrinsic or extrinsic factors influencing cell type diversity appear to act similarly across developmental time for sensory neurons.