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Updated: Oct 25, 2025

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Rhodaelectro-catalyzed access to chromones via formyl C-H activation towards peptide electro-labeling
Maximilian Stangier1, Antonis M Messinis1, João C A Oliveira1
1Institute for Organic and Biomolecular Chemistry, Georg-August-Universität Göttingen, Göttingen, Germany.
Abstract:
Chromones represent a privileged scaffold in medicinal chemistry and are an omnipresent structural motif in natural products. Chemically encoded non-natural peptidomimetics feature improved stability towards enzymatic degradation, cell permeability and binding affinity, translating into a considerable impact on pharmaceutical industry. Herein, a strategy for the sustainable assembly of chromones via electro-formyl C-H activation is presented. The rational design of the rhodaelectro-catalysis is guided by detailed mechanistic insights and provides versatile access to tyrosine-based fluorogenic peptidomimetics.
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