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Severe methanol poisoning treated with a novel hemodialysis system: a case report, analysis, and review

Alisa C Illescas1, Christos P Argyropoulos1,2, Sara A Combs1,2

  • 1Department of Internal Medicine, University of New Mexico School of Medicine, MSC10-5550, 1 University of New Mexico, Albuquerque, NM 87131 USA.

Renal Replacement Therapy
|August 9, 2021
PubMed

Insights

A methanol poisoning outbreak linked to hand sanitizer was treated using the Tablo Hemodialysis System. This novel device demonstrated effective methanol clearance, offering a new treatment option for toxic alcohol poisoning.

Area of Science:

  • Toxicology
  • Nephrology

Background:

  • An outbreak of methanol poisoning occurred in the US linked to contaminated hand sanitizer during the COVID-19 pandemic.
  • This resulted in numerous hospitalizations and fatalities in New Mexico and Arizona.

Observation:

  • This report details a case of severe methanol intoxication successfully treated with the Tablo Hemodialysis System.
  • This marks the first reported instance of toxic alcohol poisoning managed with this innovative device.

Findings:

  • Formal regression analysis estimated Tablo hemodialysis achieved a methanol clearance of 239 mL/min.
  • This clearance rate is comparable to established standards of care for toxic alcohol poisoning treatment.

Implications:

  • Highlights the efficacy of the Tablo Hemodialysis System in managing toxic alcohol ingestions.
  • Emphasizes optimizing hemodialysis with extended treatment times and high-efficiency dialyzers for intoxication management.
Keywords:
HemodialysisHemodialysis delivery systemsKineticsMethanol poisoningToxic alcohol

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