Can grape polyphenols affect glycation markers? A systematic review.
Olívia G L Coelho1, Priscila V M Ribeiro1, Rita de Cássia G Alfenas1
1Departamento de Nutrição de Saúde, Universidade Federal de Viçosa, Viçosa, Brazil.
Critical Reviews in Food Science and Nutrition
|August 9, 2021
Summary
Grape polyphenols show potential in reducing early glycation markers like fructosamine and methylglyoxal (MGO). Further research is needed to confirm their impact on advanced glycation end-products (AGEs) and related receptors in chronic diseases.
Area of Science:
- Nutritional Science
- Biochemistry
- Molecular Biology
Background:
- Advanced glycation end-products (AGEs) are implicated in chronic disease pathogenesis due to their pro-inflammatory and oxidative stress-inducing properties.
- Grape polyphenols possess known antiglycative and antioxidant properties, suggesting a role in chronic disease prevention.
- Clinical evidence linking grape polyphenol modulation of glycation markers to chronic disease prevention and treatment remains limited.
Approach:
- A systematic review adhering to PRISMA guidelines was conducted to analyze existing studies.
- Searches included terms like "grape", "resveratrol", "quercetin", and "polyphenol extract".
- Seven studies were included in the final analysis.
Key Points:
- Grape polyphenols reduced fructosamine and methylglyoxal (MGO) concentrations.
- Gene expression of endogenous secretory RAGE (esRAGE) was increased, though serum concentrations remained unaffected.
- Resveratrol's antiglycative effects were linked to MGO trapping and RAGE downregulation.
Conclusions:
- Dietary grape polyphenols demonstrate a potential positive impact on early glycation products, AGEs, and esRAGE.
- Intervention durations in current studies may have been insufficient to observe changes in certain markers like glycated hemoglobin.
- Further investigation is required to elucidate the mechanisms by which grape polyphenols modulate AGEs and their receptors in the context of chronic diseases.
Keywords:
Advanced glycation end productschronic diseaseesRAGEglycated hemoglobingrape seed extractphenolic compoundMore Related Videos
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