Photoinduced Acetylation of Anilines under Aqueous and Catalyst-Free Conditions
Yu-Ming Yang1,2, Wei Yan2, Han-Wei Hu1
1School of Pharmaceutical Science (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China.
Abstract:
A green and efficient visible-light induced functionalization of anilines under mild conditions has been reported. Utilizing nontoxic, cost-effective, and water-soluble diacetyl as photosensitizer and acetylating reagent, and water as the solvent, a variety of anilines were converted into the corresponding aryl ketones, iodides, and bromides. With advantages of environmentally friendly conditions, simple operation, broad substrate scope, and functional group tolerance, this reaction represents a valuable method in organic synthesis.
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