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Delayed Digit Replantation: What is the Evidence?
Patrick W Harbour1, Elizabeth Malphrus2, Ryan M Zimmerman3
1The Curtis National Hand Center, MedStar Union Memorial Hospital, Baltimore, MD; Department of Plastic Surgery, MedStar Georgetown University Hospital, Washington, DC.
The Journal of Hand Surgery
|August 11, 2021
Summary
Revisiting digit replantation protocols, this review finds limited evidence for strict ischemia time limits. Delayed replantation is feasible, potentially improving access and quality of care for digit amputation injuries.
Area of Science:
- Microsurgery
- Trauma Surgery
- Orthopedic Surgery
Background:
- Digit replantation surgery access is limited by traditional timing constraints.
- Ischemia time is a key factor, but current cutoffs (6 hours warm, 12 hours cold) lack robust evidence.
- Anecdotal reports often dictate these time limits, not empirical data.
Purpose of the Study:
- To critically evaluate the evidence supporting established ischemia time cutoffs for digit replantation.
- To assess the feasibility and outcomes of delayed digit replantation.
- To identify opportunities for improving digit replantation protocols and accessibility.
Main Methods:
- Systematic review of existing literature on digit amputation and replantation.
- Analysis of studies reporting outcomes based on ischemia duration.
- Evaluation of the quality and generalizability of evidence for ischemia time limits.
Main Results:
- Substantial limitations exist in the literature supporting strict ischemia time cutoffs.
- Recent evidence suggests delayed digit replantation is a viable option.
- Current protocols may lead to unnecessary delays, increased costs, and reduced availability.
Conclusions:
- Evidence-based revision of digit replantation protocols is needed.
- Challenging traditional ischemia time limits can broaden access to this critical surgery.
- Improved protocols can enhance the quality of care for digit amputation injuries.

