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Updated: Oct 25, 2025

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
Published on: July 10, 2014
Potential usefulness of enamel matrix derivative in skin and mucosal injury treatment
Sylwia Klewin-Steinböck1, Zygmunt Adamski2, Marzena Wyganowska-Świątkowska1
1Department of Dental Surgery and Periodontology, Poznan University of Medical Sciences, Poznan, Poland.
Abstract:
Enamel matrix proteins (EMP) are secreted by ameloblasts during odontogenesis. The main component of enamel protein extract is amelogenin. The extracts also contain proteins with bioactive properties similar to bone morphogenic proteins and transforming growth factor β1. Research on animal models indicates that EMP improve healing of oral mucosa wounds by stimulating the production of collagen fibers and blood vessels in the connective tissue. Success in the treatment of oral wounds prompted interest in possible applications of amelogenins in the repair of damaged skin due to similarities in histological structure between skin and mucosa.
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