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Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
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Fabrication techniques involved in developing the composite scaffolds PCL/HA nanoparticles for bone tissue
Sivasankar Murugan1, Sreenivasa Rao Parcha2
1Stem Cell Research Laboratory, Department of Biotechnology, National Institute of Technology, Warangal, Telangana, 506004, India.
Journal of Materials Science. Materials in Medicine
|August 11, 2021
Summary
This review explores Polycaprolactone/Hydroxyapatite (PCL/HA) composite scaffolds for bone tissue engineering. The 3D plotting method offers superior pore architecture, mechanical strength, and bioactivity for enhanced bone regeneration.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Biomaterials are crucial for mimicking bone extracellular matrix in tissue engineering.
- Mesenchymal stem cells (MSCs) combined with biomaterials are investigated for bone regeneration.
- Polycaprolactone (PCL) and Hydroxyapatite (HA) nanoparticles form promising composite scaffolds.
Purpose of the Study:
- To review fabrication techniques for PCL/HA composite scaffolds.
- To evaluate methods for tailoring scaffold properties for bone tissue engineering.
- To highlight the advantages of specific fabrication methods for bone regeneration.
Main Methods:
- Overview of fabrication techniques including sol-gel, rapid prototyping, electro-spinning, particulate leaching, thermally induced phase separation, and freeze-drying.
- Focus on 3D plotting for scaffold fabrication.
- Analysis of morphological, mechanical, and biodegradability properties.
Main Results:
- 3D plotting demonstrates improved pore architecture (≥600 µm pore size, 92% porosity).
- Enhanced mechanical properties exceeding 18.38 MPa were observed.
- The 3D plotting method shows good biodegradability and bioactivity for bone regeneration.
Conclusions:
- PCL/HA composite scaffolds are suitable for bone tissue engineering.
- The 3D plotting fabrication method offers significant advantages for bone regeneration applications.
- Tailored scaffold properties via 3D plotting promote effective bone tissue repair.
