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Updated: Oct 24, 2025

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma
Published on: April 25, 2025
Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma
Yujia Xia1,2, Zachary J Brown1, Hai Huang1
1Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Abstract:
Hepatocellular carcinoma (HCC) is a typical inflammation-induced cancer and displays a complex interaction between the tumor microenvironment and tumor development. Immune cells in the HCC microenvironment play both pro- and anti-tumoral roles in HCC progression. An increasing number of findings indicate that metabolic reprogramming is essential for immune cell differentiation and function. In this review, we discuss the metabolic changes of different immune cells and correlate these findings to HCC progression.
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