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Author Spotlight: Standardizing Mouse In Vivo PET Imaging with Body Conforming Molds and Automated Analysis
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Immune PET Imaging.

Osigbemhe Iyalomhe1, Michael D Farwell1

  • 1Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.

Radiologic Clinics of North America
|August 16, 2021
PubMed
Summary
This summary is machine-generated.

Fluorodeoxyglucose (FDG) PET/CT imaging helps assess cancer immunotherapy responses by detecting metabolic changes. However, distinguishing tumor uptake from inflammation caused by immune checkpoint inhibitors (ICIs) presents challenges.

Keywords:
FDGImmune imagingImmune-related adverse eventsImmunotherapyPET/CT

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Area of Science:

  • Oncology
  • Immunology
  • Nuclear Medicine

Background:

  • Cancer immunotherapy, particularly with immune checkpoint inhibitors (ICIs), has revolutionized cancer treatment.
  • Fluorodeoxyglucose (FDG) Positron Emission Tomography/Computed Tomography (PET/CT) is a key imaging modality for assessing treatment response.
  • FDG avidity can reflect both tumor metabolic activity and immune-related changes, complicating response evaluation.

Purpose of the Study:

  • To discuss the challenges in evaluating treatment response using FDG PET/CT in patients receiving ICIs.
  • To review unique response patterns and immune-related adverse events associated with ICI therapy.
  • To highlight the potential of novel immune-specific PET imaging probes.

Main Methods:

  • Review of current literature on FDG PET/CT in cancer immunotherapy.
  • Discussion of mechanisms underlying FDG uptake in tumors and inflammatory responses.
  • Exploration of emerging immune-specific PET imaging agents.

Main Results:

  • FDG PET/CT can be confounded by increased uptake in both responding tumors and inflammatory infiltrates common in ICI therapy.
  • Specific patterns of FDG uptake may indicate treatment efficacy or immune-related adverse events.
  • Novel PET probes targeting immune cells or pathways show promise for more specific imaging.

Conclusions:

  • Accurate interpretation of FDG PET/CT requires understanding the interplay between tumor and immune responses to ICIs.
  • Immune-specific PET imaging offers a potential future strategy to improve treatment monitoring and patient management.
  • These advanced imaging techniques may extend beyond oncology to other immune-mediated diseases.