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Acute and sub acute toxicity study on Sangu parpam
Ramachandran Madhavan1, Sathish Adithya2, Bupesh Giridharan3,4
1Department of Nanju Maruthuvam, National Institute of Siddha,Chennai, India.
Bioinformation
|August 16, 2021
Summary
Sangu Parpam, a Siddha medicine, shows potential for treating peptic ulcers. Acute and sub-acute toxicity analyses were conducted to assess its safety for this application.
Area of Science:
- Traditional Siddha medicine
- Pharmacology
- Toxicology
Background:
- Peptic ulcer disease is a significant health concern.
- The Siddha system of medicine classifies 4448 diseases, including peptic ulcer.
- Sangu Parpam is a known Siddha formulation used for peptic ulcer treatment.
Purpose of the Study:
- To document the acute and sub-acute toxicity of Sangu Parpam.
- To evaluate the safety profile of Sangu Parpam for potential therapeutic use in peptic ulcer.
Main Methods:
- Acute toxicity study in rodents.
- Sub-acute toxicity study in rodents.
- Standard toxicological assessments including clinical observations, hematology, and histopathology.
Main Results:
- Preliminary toxicity data for Sangu Parpam.
- Identification of potential adverse effects or safety margins.
- Establishment of a basis for further clinical investigation.
Conclusions:
- Sangu Parpam requires thorough toxicological evaluation before widespread clinical use for peptic ulcers.
- The study provides foundational safety data for Sangu Parpam.
- Further research is warranted to confirm efficacy and safety in human subjects.
