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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

998
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
998
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

769
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
769
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

898
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
898

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Related Experiment Video

Updated: Oct 24, 2025

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
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Macular Optical Coherence Tomography Imaging in Glaucoma.

Alireza Kamalipour1, Sasan Moghimi1

  • 1Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, CA, United States.

Journal of Ophthalmic & Vision Research
|August 16, 2021
PubMed
Summary
This summary is machine-generated.

Macular spectral-domain optical coherence tomography (SD-OCT) offers valuable complementary data for glaucoma assessment, aiding in early detection and risk evaluation. This technique enhances monitoring, especially in complex cases, by analyzing retinal ganglion cells in the macula.

Keywords:
GlaucomaImagingMaculaOptical Coherence TomographyArtificial Intelligence

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Spectral-domain optical coherence tomography (SD-OCT) is crucial for posterior segment eye imaging.
  • Traditional glaucoma evaluation relies on optic nerve head and peripapillary imaging.
  • Emerging evidence supports macular SD-OCT as a complementary tool in glaucoma management.

Purpose of the Study:

  • To review the clinical applications of macular SD-OCT in glaucoma.
  • To explore the future potential of macular SD-OCT for glaucoma evaluation.
  • To highlight macular SD-OCT's role alongside traditional imaging methods.

Main Methods:

  • Review of current literature on macular SD-OCT in glaucoma.
  • Analysis of macular structure and its relation to glaucomatous damage.
  • Discussion of artificial intelligence integration in glaucoma data analysis.

Main Results:

  • The macula, containing over 50% of retinal ganglion cells, is affected early in glaucoma.
  • Macular SD-OCT provides complementary information for risk assessment and early detection.
  • It is particularly useful in monitoring advanced glaucoma and specific ocular conditions.

Conclusions:

  • Macular SD-OCT is a valuable tool for comprehensive glaucoma assessment.
  • It offers insights into structural changes not always evident with optic nerve head imaging.
  • Future integration with AI can provide a more holistic view of glaucoma progression.