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Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
Published on: July 5, 2024
988
Nutrient Element Decorated Polyetheretherketone Implants Steer Mitochondrial Dynamics for Boosted Diabetic
Hao Wang1, Xinliang Fu1, Jiacheng Shi2
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|August 16, 2021
Summary
New orthopedic implants combat diabetes complications by targeting mitochondria. These implants, featuring zinc and strontium coatings, reduce bacterial infection and improve bone healing in diabetic patients.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Cell Biology
Background:
- Diabetes mellitus (DM) causes hyperglycemia, leading to mitochondrial dysfunction and high failure rates for orthopedic implants.
- Hyperglycemia-induced mitochondrial dysfunction impairs osteoblast activity and bone healing around implants.
Purpose of the Study:
- To develop novel mitochondria-targeted orthopedic implants for diabetic patients.
- To investigate the effects of dual nutrient element coatings (ZnO and Sr(OH)2) on implant performance in a hyperglycemic environment.
Main Methods:
- Synthesized sulfonated polyetheretherketone (PEEK) coated with zinc oxide (ZnO) and strontium hydroxide (Sr(OH)2) nanoparticles (Zn&Sr-SPEEK).
- Evaluated antibacterial activity, osteoblast cyto-activity, and mitochondrial function (Dynamin-related protein 1 (Drp1) gene expression, mitochondrial membrane potential (MMP), reactive oxygen species (ROS)) in vitro.
- Assessed bone remodeling and osseointegration in a diabetic rat femoral/tibia defect model.
Main Results:
- Zn&Sr-SPEEK coatings exhibited synergistic release of Zn2+ and Sr2+, showing potent antibacterial effects and enhanced osteoblast activity under hyperglycemic conditions.
- Implants effectively restored mitochondrial dynamics by down-regulating Drp1, increasing MMP, and reducing ROS.
- In vivo studies demonstrated significantly improved bone remodeling and osseointegration in diabetic rats treated with Zn&Sr-SPEEK implants.
Conclusions:
- Dual nutrient element coatings (Zn2+ and Sr2+) on PEEK implants modulate mitochondrial dynamics, promoting osteogenesis and osseointegration in diabetic patients.
- This novel orthopedic implant offers a promising solution for improving surgical outcomes in patients with diabetes mellitus.
Keywords:
mitochondrial dynamicsnutrient elementorthopedic implantosseointegrationpolyetheretherketone
