Related Experiment Videos
Metal concentrations in human pancreatic juice
N Ishihara1, A Yoshida, M Koizumi
1Center for Occupational Disease, Tohoku Rosai Hospital, Sendai, Japan.
Archives of Environmental Health
|November 1, 1987
Summary
Human pancreatic juice daily excretes essential and toxic metals, including zinc, copper, and lead. Metal concentrations in pancreatic juice showed no significant differences based on sex or pancreatic disease.
Area of Science:
- Biochemistry
- Human Physiology
- Toxicology
Background:
- Human pancreatic juice plays a role in nutrient absorption and waste elimination.
- Understanding metal concentrations in pancreatic juice is crucial for assessing toxic and essential element homeostasis.
Purpose of the Study:
- To quantify concentrations of 11 metals and protein in human pancreatic juice.
- To investigate potential differences in metal concentrations related to sex and pancreatic pathologies.
Main Methods:
- Human pancreatic juice was collected via endoscopic cannulation after secretin administration.
- Metal and protein concentrations were analyzed in 19 subjects (normal, early pancreatic cancer, chronic pancreatitis).
Main Results:
- No significant differences in metal or protein concentrations were observed between males and females.
- Pathological changes in the pancreas (cancer, pancreatitis) did not significantly alter metal concentrations.
- Daily excretion of toxic (Cd, Pb) and essential metals (Cu, Zn, Fe, Mn, Cr, Ni) into the duodenum via pancreatic juice was calculated.
Conclusions:
- Human pancreatic juice facilitates the daily excretion of both essential and toxic metals.
- Pancreatic metal excretion is not significantly influenced by sex or common pancreatic diseases.