Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials01:16

Clinical Trials

9.8K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
9.8K
Clinical Trials: Overview01:11

Clinical Trials: Overview

3.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.9K
Preclinical Development: Overview01:28

Preclinical Development: Overview

5.3K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
5.3K
Design Example: Alignment of a Road Line Using GIS01:17

Design Example: Alignment of a Road Line Using GIS

139
The alignment of a road line using Geographic Information Systems (GIS) is a critical process in civil engineering, combining advanced technology with practical decision-making. This methodology begins with the collection of geospatial data, including information on land cover, geomorphology, drainage patterns, slope, and contour details. Such data is typically acquired through satellite imagery and GIS tools, offering a comprehensive understanding of the terrain.Once the data is gathered, it...
139
Rolling Resistance: Problem Solving01:17

Rolling Resistance: Problem Solving

535
Rolling resistance, also known as rolling friction, is the force that resists the motion of a rolling object, such as a wheel, tire, or ball, when it moves over a surface. It is caused by the deformation of the object and the surface in contact with each other, as well as other factors like internal friction, hysteresis, and energy losses within the materials. Rolling resistance opposes the object's motion, requiring additional energy to overcome it and maintain movement. In practical...
535
Rolling Resistance01:21

Rolling Resistance

414
When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down...
414

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic Confidence of Contrast-Enhanced T1-Weighted MRI for the Detection of Brain Metastases: 3D FSE versus 3D GRE-Based Sequences.

AJNR. American journal of neuroradiology·2024
Same author

Correction: Detecting the percent of peripheral blood mononuclear cells displaying p-STAT-3 in malignant glioma patients.

Journal of translational medicine·2024
Same author

National Psoriasis Foundation Telemedicine Task Force guidance for management of psoriatic disease via telemedicine.

JAAD international·2023
Same author

Treatment of Scalp Psoriasis.

Journal of drugs in dermatology : JDD·2022
Same author

Treatment of Nail Psoriasis.

Journal of drugs in dermatology : JDD·2022
Same author

Intralesional Mode of Drug Administration in Psoriasis.

Journal of drugs in dermatology : JDD·2022
Same journal

Emerging T-Cell Engagers and Novel Immunotargets in Multiple Myeloma.

Oncology (Williston Park, N.Y.)·2026
Same journal

Access to Care and the Affordable Care Act: Why Do Problems Exist 15 Years Later?

Oncology (Williston Park, N.Y.)·2026
Same journal

Synchronous Endometrial and Ovarian Cancers: A Case Study and Literature Review.

Oncology (Williston Park, N.Y.)·2026
Same journal

Perceived Social Support, Anxiety, and Depression Among Women With Breast Cancer.

Oncology (Williston Park, N.Y.)·2026
Same journal

Before Certainty.

Oncology (Williston Park, N.Y.)·2026
Same journal

Adult T-Cell Leukemia/Lymphoma and Epstein-Barr Virus-Positive DLBCL: A Rare Concomitant Association.

Oncology (Williston Park, N.Y.)·2026
See all related articles

Related Experiment Video

Updated: Oct 24, 2025

Using a Virtual Reality Walking Simulator to Investigate Pedestrian Behavior
06:38

Using a Virtual Reality Walking Simulator to Investigate Pedestrian Behavior

Published on: June 9, 2020

5.0K

Clinical Trials in Progress: ROADS Trial.

Jeffrey Weinberg1

  • 1University of Texas MD Anderson Cancer Center, Houston, TX.

Oncology (Williston Park, N.Y.)
|August 16, 2021
PubMed
Summary
This summary is machine-generated.

This Phase 3 trial compares post-surgical stereotactic radiotherapy (SRT) to surgically targeted radiation therapy (STaRT) using GammaTile for brain tumors. Results will guide optimal treatment for newly diagnosed metastatic brain tumors.

More Related Videos

Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research
07:15

Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research

Published on: December 18, 2020

4.6K
Evaluating the Effect of Roadside Parking on a Dual-Direction Urban Street
14:55

Evaluating the Effect of Roadside Parking on a Dual-Direction Urban Street

Published on: January 20, 2023

3.8K

Related Experiment Videos

Last Updated: Oct 24, 2025

Using a Virtual Reality Walking Simulator to Investigate Pedestrian Behavior
06:38

Using a Virtual Reality Walking Simulator to Investigate Pedestrian Behavior

Published on: June 9, 2020

5.0K
Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research
07:15

Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research

Published on: December 18, 2020

4.6K
Evaluating the Effect of Roadside Parking on a Dual-Direction Urban Street
14:55

Evaluating the Effect of Roadside Parking on a Dual-Direction Urban Street

Published on: January 20, 2023

3.8K

Area of Science:

  • Neuro-oncology
  • Radiation Oncology
  • Clinical Trials

Background:

  • Metastatic brain tumors present a significant clinical challenge, often requiring multimodal treatment approaches.
  • Surgical resection followed by adjuvant radiotherapy is a standard of care, but optimal radiation techniques are under investigation.

Purpose of the Study:

  • To compare the efficacy and safety of post-surgical stereotactic radiotherapy (SRT) versus surgically targeted radiation therapy (STaRT) using GammaTile in patients with newly diagnosed metastatic brain tumors.

Main Methods:

  • A Phase 3 randomized controlled trial (ROADS; NCT04365374) involving patients with newly diagnosed metastatic brain tumors.
  • Patients were randomized to receive either SRT or STaRT with GammaTile after surgical resection.

Main Results:

  • This section is pending study completion and data analysis.

Conclusions:

  • This trial aims to determine the superior radiation strategy for patients with metastatic brain tumors, potentially improving outcomes and guiding future treatment protocols.