Three-Component Couplings among Heteroarenes, Difluorocyclopropenes, and Water via C-H Activation
Xuexin Liu1, Jian Chen1, Chunyan Yang1
1West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Abstract:
Three-component couplings have been realized for efficiently constructing various nitrogen-containing skeletons via C-H activation, where difluorocyclopropenes have been first identified as coupling partners. Many substrates including sp2 and sp3 C-H substrates were well tolerated, furnishing the corresponding products in good yields. Furthermore, a catalyst-dependent reaction was also developed, enabling divergent construction of two different frameworks. The application value of these reactions was demonstrated in gram-scale experiments with as little as 1 mol % catalyst.
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