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Flow Injection Techniques for Tetracycline Quantification: A Review.

Mohammed D Y Oteef1, Abubakr M Idris2,3

  • 1Department of Chemistry, College of Science, Jazan University, Jazan, Saudi Arabia.

Critical Reviews in Analytical Chemistry
|August 17, 2021
PubMed
Summary

Flow injection (FI) techniques offer efficient and safe methods for assaying tetracycline in diverse samples. This review highlights FI

Keywords:
Bead injection analysisflow injection analysissequential injection analysissequential injection chromatographytetracycline

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Area of Science:

  • Analytical Chemistry
  • Pharmaceutical Analysis

Background:

  • Tetracycline's therapeutic importance necessitates reliable analytical methods.
  • Flow injection (FI) analysis is a versatile technique with multiple generations and versions.

Purpose of the Study:

  • To review the application of flow injection (FI) techniques for tetracycline assay development.
  • To cover over forty FI-based methods for tetracycline quantification.

Main Methods:

  • Comprehensive literature review of FI techniques for tetracycline analysis.
  • Analysis of methods across various matrices, including standard solutions, pharmaceutical formulations, biological fluids, and food.

Main Results:

  • FI techniques offer advantages in reagent consumption, sample frequency, accuracy, and safety.
  • FI methods are simple, cost-effective, and applicable to diverse sample types.
  • The review encompasses over forty methods from FI's inception to the present.

Conclusions:

  • Flow injection techniques are highly suitable for developing robust and efficient tetracycline assay methods.
  • FI analysis provides a practical and advantageous approach for quantifying tetracycline in various complex matrices.