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Related Concept Videos

Glial Cells

Glial Cells

Nervous Tissue: Glial Cells

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

Types of RNA

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Oct 23, 2025

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Functions of noncoding RNAs in glial development.

Jiarui Wu¹, Haoyang Yu¹, Hao Huang²

¹State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.

Developmental Neurobiology

|August 17, 2021

Summary

This summary is machine-generated.

Noncoding RNAs (ncRNAs) are crucial regulators of glial development, influencing processes like proliferation and differentiation. This review highlights how microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) control glial formation and signaling pathways.

Keywords:

gliogenesis lncRNA miRNA ncRNA

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Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Glia are vital cells in the central nervous system, involved in metabolism, signal transduction, and development.
Glial development encompasses proliferation, differentiation, and migration, requiring intricate regulatory networks.
Noncoding RNAs (ncRNAs) play significant roles in gene regulation during nervous system development.

Purpose of the Study:

To review the regulatory roles of ncRNAs in glial development.
To focus on the involvement of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) in glial formation.
To elucidate how ncRNAs modulate signaling pathways critical for glial development.

Main Methods:

Literature review of ncRNAs in glial development.
Classification and functional description of ncRNAs.
Focus on specific roles of miRNAs and lncRNAs in glial biology.

Main Results:

ncRNAs are deeply involved in regulating glial development.
miRNAs and lncRNAs extensively participate in glial formation.
These ncRNAs actively regulate signaling pathways essential for glial development.

Conclusions:

ncRNAs are key players in the complex processes of glial development.
Understanding ncRNA regulation provides insights into neurological diseases.
This review establishes a foundation for future research on glial development and related pathologies.