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Basophil Activation Test for Allergy Diagnosis
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[Allergen immunotherapy: FAQs and facts].

V Mortasawi1, W Pfützner2

  • 1Klinik für Dermatologie und Allergologie, Universitätsklinikum Marburg, Baldingerstr., 35043, Marburg, Deutschland. v.mortasawi@gmail.com.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|August 17, 2021
PubMed
Summary
This summary is machine-generated.

Allergen immunotherapy (AIT), including subcutaneous (SCIT), sublingual (SLIT), and oral forms, offers causal treatment for IgE-mediated allergies when avoidance fails. Careful consideration of indications, contraindications, and risks is crucial for safe and effective patient management.

Keywords:
AllergyHymenoptera venom allergyRisk factorsSubcutaneous injection immunotherapySublingual immunotherapy

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Area of Science:

  • Immunology
  • Allergy and Clinical Immunology
  • Pharmacology

Background:

  • Allergen immunotherapy (AIT) is the sole causative treatment for IgE-mediated allergies unresponsive to allergen avoidance.
  • AIT encompasses subcutaneous injection (SCIT), sublingual application (SLIT), and recently approved oral immunotherapy for food allergies.

Purpose of the Study:

  • To provide frequently asked questions (FAQs) and facts regarding the implementation of AIT.
  • To discuss the risk management strategies associated with AIT.
  • To guide decision-making for initiating and managing AIT.

Main Methods:

  • Review of current practices and guidelines for allergen immunotherapy.
  • Discussion of indications, contraindications, and potential side effects.
  • Presentation of risk management protocols for AIT.

Main Results:

  • AIT is effective for allergies to aeroallergens and Hymenoptera venoms.
  • SCIT, SLIT, and oral immunotherapy are established administration routes.
  • Potential for serious adverse events necessitates careful patient selection and monitoring.

Conclusions:

  • Accurate diagnosis and appropriate patient selection are paramount for successful AIT.
  • Risk assessment and management are essential components of AIT protocols.
  • AIT offers a valuable therapeutic option for specific allergic conditions when managed correctly.