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Related Experiment Video

Updated: Oct 23, 2025

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

Ischemic Choroidal Diseases.

Teresa Barth¹, Horst Helbig¹

¹Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Regensburg, Deutschland.

Klinische Monatsblatter Fur Augenheilkunde

|August 20, 2021

Summary

This summary is machine-generated.

Choroidal ischemia, often underdiagnosed, presents varied clinical patterns based on vascular structure. Management focuses on cardiovascular risk and associated diseases due to limited therapeutic options.

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Published on: August 11, 2023

Area of Science:

Ophthalmology
Vascular Biology
Medical Imaging

Background:

Ischemic choroidal diseases are underdiagnosed, with clinical presentations varying by vascular structure size and location.
Recognizing specific signs like Amalric sign, Siegrist streaks, and Elschnig spots is crucial for diagnosis.

Purpose of the Study:

To review the clinical presentation, causes, and management of ischemic choroidal diseases.
To highlight the role of advanced imaging in visualizing choroidal vasculature.

Main Methods:

Review of clinical presentations of choroidal ischemia, including specific signs associated with different vascular occlusions.
Discussion of etiological factors, including systemic diseases and local inflammation.
Integration of recent advances in imaging technologies like EDI-OCT and OCT-A.

Main Results:

Occlusion of long posterior ciliary arteries leads to characteristic triangular patches (Amalric sign) and retinal pigment epithelium atrophy.
Smaller vessel ischemia manifests as multifocal lesions (Elschnig spots), while vortex vein occlusion causes peripheral swelling.
Systemic conditions (hypertension, vasculitis, lupus) and local inflammation (APMPPE) are significant causes; iatrogenic origins are rare.

Conclusions:

Management strategies for choroidal ischemia are limited, emphasizing cardiovascular risk factor optimization and treatment of co-existing ocular and systemic conditions.
Advanced imaging techniques significantly improve the visualization of choroidal vasculature, aiding diagnosis and understanding of pathologies in conditions like AMD and diabetes.