Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation01:37

Neural Regulation

40.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.6K
Neuromuscular Junction And Blockade01:29

Neuromuscular Junction And Blockade

3.9K
The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
3.9K
Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

3.0K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
3.0K
The Neuromuscular Junction01:19

The Neuromuscular Junction

14.5K
The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
14.5K
Motor Unit Stimulation01:20

Motor Unit Stimulation

2.7K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
2.7K
Nondepolarizing (Competitive) Neuromuscular Blockers: Mechanism of Action01:17

Nondepolarizing (Competitive) Neuromuscular Blockers: Mechanism of Action

2.3K
Nondepolarizing neuromuscular blockers induce paralysis by competitively blocking nicotinic acetylcholine receptors at the muscle end plate. Examples include pancuronium, mivacurium, vecuronium, and rocuronium. These quaternary ammonium derivatives are administered intravenously, are poorly absorbed, and are excreted via the kidneys.
Competitive antagonists prevent acetylcholine from binding to its receptor, inhibiting membrane depolarization. Without conformational changes or intrinsic...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating Use of Chat-Generative Pretrained Transformer for Patient Education of Pelvic Floor Disorders.

Urogynecology (Philadelphia, Pa.)·2026
Same author

Evaluation of AI-Generated Surgical Decision Aids for Pelvic Floor Disorders.

Urogynecology (Philadelphia, Pa.)·2026
Same author

Risk Factors for De Novo Overactive Bladder After Midurethral Sling.

Urogynecology (Philadelphia, Pa.)·2023
Same author

Transvaginal Mesh Compared With Native Tissue Repair for Pelvic Organ Prolapse.

Obstetrics and gynecology·2022
Same author

Ceftaroline vs vancomycin for the treatment of acute pulmonary exacerbations in pediatric patients with cystic fibrosis.

Pediatric pulmonology·2020
Same author

Clinical implications of self-neglect among patients in community settings.

British journal of community nursing·2019
Same journal

Bridging Science and Practice in Gender-Affirming Care: A Compendium for Gynecologists.

Obstetrics and gynecology clinics of North America·2026
Same journal

Evidence, Clinical Expertise, and Research Gaps in Gender-Affirming Care.

Obstetrics and gynecology clinics of North America·2026
Same journal

Evaluation and Management of the Pediatric Gender-Diverse Patient.

Obstetrics and gynecology clinics of North America·2026
Same journal

Expanding Access to Cervical Cancer Screening for Transgender and Nonbinary Individuals.

Obstetrics and gynecology clinics of North America·2026
Same journal

Updates on Breast Cancer Screening and Special Considerations for Transgender Men and Women.

Obstetrics and gynecology clinics of North America·2026
Same journal

Contraceptive Needs of the Transmasculine Patient.

Obstetrics and gynecology clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Oct 23, 2025

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

13.3K

Neuromodulation.

Karen Noblett1, Carly Crowder1

  • 1Department of Obstetrics & Gynecology, University of California, Irvine, 101 The City Drive South, Orange, CA 92686, USA.

Obstetrics and Gynecology Clinics of North America
|August 21, 2021
PubMed
Summary
This summary is machine-generated.

Sacral neuromodulation (SNM) offers proven long-term success for bladder and bowel incontinence. Recent advancements enhance implant techniques and technology for improved patient outcomes in contemporary practice.

Keywords:
AxonicsFecal incontinenceInterStimSacral neuromodulationUrinary retentionUrinary urgency incontinence

More Related Videos

Focused Ultrasound Neuromodulation of Human In Vitro Neural Cultures in Multi-Well Microelectrode Arrays
04:00

Focused Ultrasound Neuromodulation of Human In Vitro Neural Cultures in Multi-Well Microelectrode Arrays

Published on: May 3, 2024

1.6K
Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation
04:59

Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation

Published on: January 19, 2024

2.8K

Related Experiment Videos

Last Updated: Oct 23, 2025

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

13.3K
Focused Ultrasound Neuromodulation of Human In Vitro Neural Cultures in Multi-Well Microelectrode Arrays
04:00

Focused Ultrasound Neuromodulation of Human In Vitro Neural Cultures in Multi-Well Microelectrode Arrays

Published on: May 3, 2024

1.6K
Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation
04:59

Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation

Published on: January 19, 2024

2.8K

Area of Science:

  • Urology
  • Neurology
  • Gastroenterology

Background:

  • Sacral neuromodulation (SNM) has been a guideline-recommended therapy for over 20 years.
  • It is effective for urinary urgency incontinence, urinary urgency frequency, nonobstructive urinary retention, and fecal incontinence.
  • The initial surgical approach for SNM was more invasive.

Purpose of the Study:

  • To review recent advancements in sacral neuromodulation (SNM) therapy.
  • To update best practices for SNM implant techniques.
  • To discuss technological innovations and new clinical literature in SNM.

Main Methods:

  • Review of recent advancements in SNM therapy.
  • Analysis of updates in best practices for implant technique.
  • Evaluation of technological innovations and new clinical literature.

Main Results:

  • SNM has a long-term proven success rate for various incontinence conditions.
  • Recent advancements have led to less invasive implant techniques.
  • Technological innovations continue to improve SNM therapy.

Conclusions:

  • Sacral neuromodulation (SNM) remains a valuable therapeutic option.
  • Contemporary practice benefits from updated implant techniques and technological advancements.
  • Continued research and literature review are essential for optimizing SNM outcomes.