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[Hepatitis B virus infection and glomerulonephritis]
Insights
Hepatitis B virus (HBV) markers like HBsAg were more prevalent in patients with glomerulonephritis (GN) compared to other kidney diseases. This suggests a potential link between HBV infection and GN development.
Area of Science:
- Nephrology
- Virology
- Immunology
Context:
- Glomerulonephritis (GN) is a significant kidney disease with diverse etiologies.
- Hepatitis B virus (HBV) infection is a global health concern with potential systemic implications.
- The association between HBV and GN requires further investigation.
Purpose:
- To investigate the prevalence of Hepatitis B virus (HBV) markers in patients with glomerulonephritis (GN).
- To compare HBV marker frequency in GN patients with those suffering from other renal diseases.
Summary:
- Hepatitis B surface antigen (HBsAg) was detected in 21.1% of glomerulonephritis (GN) patients, significantly higher than in patients with other kidney diseases (8.3%).
- Anti-HBs antibodies were found in 20.3% of GN patients, similar to HBsAg prevalence.
- Hepatitis B e-antigen (HBeAg) was present in 3 of 15 chronic GN patients with HBsAg, while anti-HBe was detected in 6 chronic GN patients. HBsAg was also detected in one kidney biopsy from 16 GN patients.
Impact:
- Findings suggest a potential association between Hepatitis B virus (HBV) infection and the pathogenesis of glomerulonephritis (GN).
- Highlights the importance of screening for HBV markers in GN patients for comprehensive disease management.
- May inform future research into the role of viral infections in kidney diseases.
Abstract:
HBsAg was detected in the blood serum of patients with glomerulonephritis (GN) in 21.1% of cases. During examination of patients with other diseases of the kidneys HBsAg was detected in the blood serum much less frequently (8.3%). In patients with systemic autoimmune diseases it was found in 12.1%, in patients with pyelonephritis and amyloidosis in 7.4%. Anti-HBs and HBsAg in GN patients were defined with equal frequency (20.3%). Among patients with other renal diseases anti-HBs were found more frequently in systemic autoimmune diseases (36.7%). The presence of the other hepatitis B virus marker (HBeAg) was noted in 3 out of 15 patients with chronic GN with HBSAg in the blood serum and was undetectable in either of 3 patients with HBsAg in the group with some other renal diseases. Anti-HBe were detected in 6 patients with chronic GN. Of 16 GN patients HBsAg was detected in a kidney biopsy specimen of one patient.