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Updated: Oct 23, 2025

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Advances in the development of HIV integrase strand transfer inhibitors
Yue Wang1, Shuang-Xi Gu2, Qiuqin He1
1Department of Chemistry, Fudan University, 2005 Songhu Road, Yangpu District, Shanghai, 200438, China.
Abstract:
HIV-1 integrase (IN) is a key enzyme in viral replication that catalyzes the covalent integration of viral cDNA into the host genome. Currently, five HIV-1 IN strand transfer inhibitors (INSTIs) are approved for clinical use. These drugs represent an important addition to the armamentarium for antiretroviral therapy. This review briefly illustrates the development history of INSTIs. The characteristics of the currently approved INSTIs, as well as their future perspectives, are critically discussed.
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