A concise review on the role of BDNF-AS in human disorders

Brain-derived neurotrophic factor-antisense (BDNF-AS) is a long non-coding RNA with tens of alternatively spliced variants being transcribed from 11p14 cytogenetic band. As a naturally occurring anti-sense, it regulates expression of BDNF, a factor which as essential roles in the pathoetiology of neurodevelopmental diseases. Notably, BDNF-AS has been reported to be down-regulated in colorectal cancer, osteosarcoma, esophageal cancer, glioblastoma, prostate cancer, cervical cancer and breast cancer. This lncRNA has direct/indirect functional interactions with GSK-3β, EZH2, miR-214, PABPC1, RAX2, DLG5, p53 and ADAR as well as RNH1/TRIM21/mTOR signaling. In prostate and breast cancers, down-regulation of BDNF-AS has been associated with poor clinical outcome. In the present review, we assessed the existing literature on the role of BDNF-AS in this process and summarized the available data in three distinct sections based of the methodology of experiments and source of expression assays. We also summarized the role of BDNF-AS in non-neoplastic conditions.