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Rituximab-induced acute lympholysis and pancytopenia after COVID-19 vaccination

Victoria S Leung1, Yuankai Lin2,3

  • 1Pharmacy Department Veteran Affairs Central California Health Care System (VACCHCS) Fresno CA USA.

Clinical Case Reports
|August 25, 2021
PubMed

Rituximab and COVID-19 vaccine can cause massive hyperacute depletion of B cells and plasma cells, as well as subsequent cytokine release syndrome, coagulopathy, and pancytopenia. These effects differ from the adverse effects that have been reported for rituximab, and new guidelines regarding the timing of rituximab infusion and vaccination are urgently needed.

Keywords:
COVID‐19 vaccinelympholysispancytopeniarituximab

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