Eosinophilic Fasciitis With a Malignant Outcome

Area of Science:

• Dermatology
• Rheumatology

Background:

• Eosinophilic fasciitis (EF) is a rare, localized fibrosing condition affecting fascial layers, with fewer than 300 reported cases globally.
• Limited prevalence hinders comprehensive research into EF pathogenesis and treatment.
• Long-term prognosis and associated comorbidities of EF remain poorly understood.

Observation:

• A 72-year-old female patient with a diagnosis of Eosinophilic fasciitis (EF).
• The patient subsequently developed squamous cell carcinoma (SCC) of the skin.
• The SCC appeared in areas previously affected by active EF.

Findings:

• This case details the first reported instance of squamous cell carcinoma (SCC) of the skin arising in a patient with a history of Eosinophilic fasciitis (EF).
• The SCC developed specifically in the same skin areas that were previously involved by EF.

Implications:

• This finding suggests a potential link between Eosinophilic fasciitis (EF) and the subsequent development of squamous cell carcinoma (SCC).
• Highlights the need for increased surveillance for skin malignancies in patients with a history of EF.
• Underscores the importance of further research into the long-term complications and potential oncogenic associations of EF.