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Published on: May 21, 2014
GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease
Daria Hajka1, Bartosz Budziak1, Łukasz Pietras1
1Department of Molecular Physiology and Neurobiology, University of Wrocław, Sienkiewicza 21 Street, 50-335 Wrocław, Poland.
Abstract:
Glycogen synthase kinase 3 (GSK3) was initially isolated as a critical protein in energy metabolism. However, subsequent studies indicate that GSK-3 is a multi-tasking kinase that links numerous signaling pathways in a cell and plays a vital role in the regulation of many aspects of cellular physiology. As a regulator of actin and tubulin cytoskeleton, GSK3 influences processes of cell polarization, interaction with the extracellular matrix, and directional migration of cells and their organelles during the growth and development of an animal organism. In this review, the roles of GSK3-cytoskeleton interactions in brain development and pathology, migration of healthy and cancer cells, and in cellular trafficking of mitochondria will be discussed.
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