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Effect of Strontium-Doped Bioactive Glass on Preventing Formation of Demineralized Lesion
Lin-Lu Dai1, May-Lei Mei2, Chun-Hung Chu1
1Faculty of Dentistry, The University of Hong Kong, Hong Kong.
Abstract:
This study investigated the effect of strontium-doped bioactive glass (SBAG) on the formation of dental demineralized lesions.
Materials And Methods:
The study materials were 48 sound human tooth specimens with both dentine and enamel, divided equally into four groups: Group 1 (SBAG), Group 2 (SBAG+Fluoride), Group 3 (Fluoride), and Group 4 (Water as control). After 14 days of pH cycling, the surface morphology of the specimens was observed by scanning electron microscopy. Crystal characteristics of the precipitates were assessed by X-ray diffraction (XRD). Micro-CT was used to measure the mineral loss and the depths of the demineralized lesions formed.
Results:
Exposure of collagen in inter-tubular areas in dentine was seen in the control group (Group 4) but not in Groups 1 to 3. In Group 2, there were obvious granular particles on the surface of the dentine. XRD revealed precipitation of apatites on the surface of the tooth specimens in Groups 1 to 3. The mean lesion depths in dentine were 81.80 μm, 30.68 μm, 39.04 μm, and 146.36 μm in Groups 1 to 4, respectively (p < 0.001). Lesions in enamel were only found in the control group. The mean mineral loss values in the dentine lesions were 1.25 g/cm3, 0.88 g/cm3, 0.87 g/cm3, and 1.65 g/cm3, in Groups 1 to 4, respectively (p < 0.001).
Conclusion:
Strontium-doped bioactive glass has a preventive effect on the formation of demineralized lesions in enamel and dentine.
