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Updated: Oct 22, 2025

Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring
Published on: May 21, 2017
[The lethal triad of hemorrhage]
Rachel Borowko1, Pierre-Olivier Vignon1, Noémie Lutz1
1Structure des urgences, hôpital d'instruction des armées Legouest, rue des Frères-Lacretelle, 57000 Metz, France.
Trauma patients with hemorrhage face a lethal triad of coagulopathy, acidosis, and hypothermia. Early interventions like bleeding control and temperature management are crucial for survival.
Area of Science:
- Trauma care
- Hemorrhagic shock management
- Critical care medicine
Background:
- Hemorrhage in trauma patients can lead to a lethal triad: coagulopathy, acidosis, and hypothermia.
- This cascade significantly increases mortality if not managed promptly.
Purpose of the Study:
- To outline an adapted management strategy for trauma patients with acute hemorrhage.
- To emphasize the importance of early interventions in pre-hospital and in-hospital settings.
Main Methods:
- Focus on pre-hospital management: rapid bleeding control, hypothermia prevention, limited fluid resuscitation, and early vasoactive amine use.
- Discuss in-hospital strategies: adapted transfusion protocols to support hemostasis procedures.
Main Results:
- Pre-hospital transfusion remains infrequent.
- In-hospital transfusion strategies are vital for supporting surgical or radiological hemostasis.
Conclusions:
- Adapted pre-hospital care is essential to prevent the lethal triad in trauma patients.
- Timely and appropriate transfusion strategies are critical for improving outcomes in hemorrhagic trauma.
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