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New Insights on Tramadol and Immunomodulation
Iqira Saeed1, Adam La Caze1, Markus W Hollmann2
1School of Pharmacy, University of Queensland, 20 Cornwall Street, Woolloongabba, Australia.
Current Oncology Reports
|August 27, 2021
Summary
Tramadol may be a preferred opioid for cancer patients as it preserves anti-cancer immunity. This review highlights tramadol
Area of Science:
- Oncology
- Immunology
- Pharmacology
Background:
- Opioids are commonly used in cancer care but may suppress anti-cancer immunity.
- Concerns exist regarding opioid-induced tumor growth and metastasis.
- Tramadol is investigated for its potential immunomodulatory effects in cancer patients.
Purpose of the Study:
- To review the literature on the immunomodulatory effects of tramadol.
- To assess tramadol's potential role in cancer treatment regarding immune response.
- To evaluate if tramadol preserves or promotes anti-cancer immunity.
Main Methods:
- Literature review of studies on tramadol and immunomodulation.
- Analysis of clinical evidence regarding tramadol's effects on the immune system.
- Examination of tramadol's impact on immune cell activity relevant to cancer defense.
Main Results:
- Tramadol demonstrates anti-inflammatory properties.
- Tramadol preserves key immune signaling pathways crucial for anti-cancer defense.
- Evidence suggests tramadol promotes or preserves natural killer cell activity.
Conclusions:
- Tramadol may be a favorable opioid choice for cancer patients due to its immune-preserving properties.
- Tramadol's immunomodulatory effects support its use in managing cancer pain while potentially aiding anti-cancer immunity.
- Further research into tramadol's role in enhancing anti-cancer immunity is warranted.
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