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Published on: February 9, 2019
Encapsulation of Active Pharmaceutical Ingredients in Lipid Micro/Nanoparticles for Oral Administration by
Carmen S Favaro-Trindade1, Fernando E de Matos Junior1, Paula K Okuro1
1Faculty of Animal Sciences and Food Engineering (FZEA), University of São Paulo, Rua Duque de Caxias, 225, Jardim Elite, Pirassununga 13625-900, Brazil.
Abstract:
Nanoencapsulation via spray cooling (also known as spray chilling and spray congealing) has been used with the aim to improve the functionality, solubility, and protection of drugs; as well as to reduce hygroscopicity; to modify taste and odor to enable oral administration; and many times to achieve a controlled release profile. It is a relatively simple technology, it does not require the use of low-cost solvents (mostly associated to toxicological risk), and it can be applied for lipid raw materials as excipients of oral pharmaceutical formulations. The objective of this work was to revise and discuss the advances of spray cooling technology, with a greater emphasis on the development of lipid micro/nanoparticles to the load of active pharmaceutical ingredients for oral administration.
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