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Published on: January 4, 2018
Dehydrogenative Azolation of Arenes in a Microflow Electrochemical Reactor
Laura Buglioni1, Marko Beslać1, Timothy Noël2
1Department of Chemical Engineering and Chemistry, Micro Flow Chemistry & Synthetic Methodology, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands.
Abstract:
The electrochemical synthesis of aryl azoles was performed for the first time in a microflow reactor. The reaction relies on the anodic oxidation of the arene partners making these substrates susceptible for C-H functionalization with azoles, thus requiring no homogeneous transition-metal-based catalysts. The synthetic protocol benefits from the implementation of a microflow setup, leading to shorter residence times (10 min), compared to previously reported batch systems. Various azolated compounds (22 examples) are obtained in good to excellent yields.
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