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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
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Bone Formation by Intramembranous Ossification01:29

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
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Satellite Stem Cells and Muscular Dystrophy01:21

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Formation of Muscle Fibers from Myoblasts01:13

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De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
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Bone Formation by Endochondral Ossification01:24

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Direct Mouse Trauma/Burn Model of Heterotopic Ossification
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Non-traumatic myositis ossificans.

Nidhin Rehman1, Harish Sadashiva2, Manoj Gopal Madakshira1

  • 1Command Hospital, Department of Laboratory Medicine, Lucknow, Uttar Pradesh, India.

Autopsy & Case Reports
|August 30, 2021
PubMed
Summary
This summary is machine-generated.

Myositis ossificans, a benign bone growth in muscle, can present without trauma, posing diagnostic challenges. This study details a rare non-traumatic case in a young girl, highlighting literature on this subtype.

Keywords:
Diagnostic ImagingMyositis OssificansPathology

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Area of Science:

  • Orthopedics
  • Pathology
  • Radiology

Background:

  • Myositis ossificans (MO) is a benign ossifying lesion typically affecting skeletal muscle.
  • Non-traumatic MO presents diagnostic and management challenges due to similarities with traumatic forms.
  • Lesion characteristics and management vary based on the stage of myositis ossificans.

Purpose of the Study:

  • To describe a rare case of non-traumatic myositis ossificans in the latissimus dorsi muscle of a young female.
  • To review the literature concerning the non-traumatic subtype of myositis ossificans.
  • To discuss the diagnostic and management implications of non-traumatic MO.

Main Methods:

  • Case report of a young girl with non-traumatic myositis ossificans.
  • Review of existing literature on non-traumatic myositis ossificans.
  • Analysis of radiological and histopathological features.

Main Results:

  • A case of non-traumatic myositis ossificans was identified in the latissimus dorsi.
  • Radiological and histopathological findings were consistent with MO, despite the absence of trauma.
  • Literature review confirmed the rarity and diagnostic challenges of non-traumatic MO.

Conclusions:

  • Non-traumatic myositis ossificans is a rare entity that requires careful evaluation due to overlapping features with traumatic forms.
  • Accurate diagnosis and appropriate management depend on understanding the variable presentation of MO.
  • Further research into the etiology and optimal treatment of non-traumatic MO is warranted.