Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder.

Nature communications·2026
Same author

Running therapy reorganizes dynamic brain networks linked to symptom improvement in affective disorders.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Barriers and facilitators to implementing deep brain stimulation for psychiatric disorders: a systematic review.

Translational psychiatry·2026
Same author

Toward trustworthy clinical AI for obsessive-compulsive disorder: reliability, generalizability, and interpretability of a transformer model across the ENIGMA-OCD consortium.

medRxiv : the preprint server for health sciences·2026
Same author

Neural variability across the transition to motherhood: Enhanced moment-to-moment neural variability during mentalizing in first-time mothers.

Journal of neuroendocrinology·2026
Same author

Pregnancy changes the variability of brain signaling.

NeuroImage·2026
Same journal

Diffusion MRI of white matter alterations in chronic traumatic brain injury: a systematic review and meta-analysis.

NeuroImage. Clinical·2026
Same journal

Decoding functional changes in the brain following ischemic stroke: a multimodal feature approach integrating fNIRS with machine learning and deep learning.

NeuroImage. Clinical·2026
Same journal

Structural brain alterations in chronic primary pain: a multimodal MRI study.

NeuroImage. Clinical·2026
Same journal

Using functional MRI neurofeedback to modulate self-blame in major depressive disorder: A pilot study.

NeuroImage. Clinical·2026
Same journal

Language network reorganization in temporal lobe epilepsy: insights from task-based functional MRI.

NeuroImage. Clinical·2026
Same journal

Functional brain biomarkers of self-referential bias in remitted depressed outpatients: a randomized controlled trial.

NeuroImage. Clinical·2026
See all related articles

Related Experiment Video

Updated: Oct 22, 2025

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
08:36

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

Published on: July 12, 2012

15.2K

White matter abnormalities in misophonia.

Nadine Eijsker1, Arjan Schröder1, Luka C Liebrand2

  • 1Amsterdam University Medical Centers, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands; Amsterdam Brain and Cognition, University of Amsterdam, Nieuwe Achtergracht 129, Amsterdam 1001 NK, the Netherlands.

Neuroimage. Clinical
|August 30, 2021
PubMed
Summary
This summary is machine-generated.

This study found that individuals with misophonia (a disorder triggered by specific sounds) exhibit both macro and microstructural white matter (WM) abnormalities. These brain differences may underlie altered social-emotional and attention processing in misophonia patients.

Keywords:
AttentionDiffusion tensor imagingMisophoniaProbabilistic tractographyWhite matter volume

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.6K
A Protocol for the Administration of Real-Time fMRI Neurofeedback Training
07:05

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training

Published on: August 24, 2017

11.2K

Related Experiment Videos

Last Updated: Oct 22, 2025

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
08:36

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

Published on: July 12, 2012

15.2K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.6K
A Protocol for the Administration of Real-Time fMRI Neurofeedback Training
07:05

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training

Published on: August 24, 2017

11.2K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Misophonia is characterized by strong negative emotional and physiological responses to specific sounds.
  • Neurobiological evidence for misophonia is limited, prompting investigation into white matter (WM) integrity.
  • WM abnormalities are observed in various psychiatric disorders, suggesting a potential link.

Purpose of the Study:

  • To investigate macro and micro-structural white matter (WM) differences in misophonia patients compared to healthy controls.
  • To explore the relationship between WM alterations and misophonia symptomatology.
  • To identify potential neurobiological underpinnings of altered social-emotional and attention processing in misophonia.

Main Methods:

  • Acquisition of T1-weighted and diffusion-weighted MRI scans from 24 misophonia patients and 25 matched controls.
  • Voxel-based morphometry (VBM) for macro-structural WM volume analysis.
  • Probabilistic tractography and diffusion tensor imaging (DTI) metrics (FA, MD, RD) for micro-structural analysis, including tract-based spatial statistics (TBSS).

Main Results:

  • Misophonia patients exhibited greater left-hemispheric WM volumes in specific tracts (Inferior Fronto-Occipital Fasciculus, Anterior Thalamic Radiation, Corpus Callosum).
  • Patients showed lower averaged radial and mean diffusivities.
  • Widespread clusters of lower mean diffusivity were identified in patients, indicating microstructural alterations.

Conclusions:

  • The study identified both macro and microstructural white matter (WM) abnormalities in individuals with misophonia.
  • These WM alterations are associated with misophonia symptoms.
  • Findings suggest a neurobiological basis for misophonia, potentially impacting social-emotional and attention processing.