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PGK1 : An Essential Player in Modulating Tumor Metabolism
Leslie Duncan1, Chloe Shay2, Yong Teng3,4,5
1Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.
Methods in Molecular Biology (Clifton, N.J.)
|September 2, 2021
Summary
Phosphoglycerate kinase 1 (PGK1) is crucial in cancer, with intracellular forms promoting tumor growth and extracellular forms inhibiting it. Understanding PGK1
Area of Science:
- Biochemistry and Molecular Biology
- Cancer Research
- Enzymology
Background:
- Phosphoglycerate kinase 1 (PGK1) is a key glycolytic enzyme generating ATP.
- PGK1 also functions in DNA replication, repair, and the tricarboxylic acid cycle.
- Posttranslational modifications (methylation, phosphorylation, acetylation) activate PGK1 in cancer.
Purpose of the Study:
- To summarize current knowledge on PGK1 mechanisms and effects in various tumor types.
- To evaluate the prognostic and therapeutic potential of PGK1 in cancer.
- To explore natural products for combating PGK1-associated cancers.
Main Methods:
- Literature review and data summarization.
- Analysis of PGK1's dual role (intracellular vs. extracellular) in cancer.
- Evaluation of PGK1's association with tumorigenesis, progression, and treatment resistance.
Main Results:
- High intracellular PGK1 levels correlate with tumorigenesis, progression, and chemoradiotherapy resistance.
- High extracellular PGK1 levels suppress angiogenesis, counteracting malignancy.
- PGK1 exhibits context-dependent roles in cancer development and progression.
Conclusions:
- PGK1 is a significant factor in cancer, with opposing intracellular and extracellular functions.
- PGK1 holds potential as a prognostic biomarker and therapeutic target in oncology.
- Further research into natural products targeting PGK1 may offer novel cancer treatment strategies.
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