Palladium-Catalyzed Intramolecular Cross-Coupling of Unactivated C(sp3)-H and C(sp2)-H Bonds
Zhuo Wu1, Zechen Wu1, Xueliang Sun1
1School of Chemical Science and Engineering, Shanghai Key Laboratory of Chemical Assessment and Sustainability, Tongji University, 1239 Siping Road, Shanghai 200092, China.
Abstract:
Direct C-H/C-H coupling represents an appealing method for the construction of C-C bonds, and the cross-coupling of unactivated C(sp3)-H and C(sp2)-H bonds is challenging and remains to be investigated. We have developed the Pd-catalyzed intramolecular coupling of inert C(sp3)-H and C(sp2)-H bonds. The reaction proceeded by o-methyl oxime-directed aryl C(sp2)-H activation and subsequent alkyl C(sp3)-H cleavage, generating C(sp2),C(sp3)-palladacycles as the key intermediates. Dihydrobenzofurans and indanes were formed as the final products.
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