Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Experimental RNAi02:15

Experimental RNAi

6.5K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.5K
Channel Rhodopsins01:11

Channel Rhodopsins

2.8K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanochemical Sulfur-Phenolate Exchange Click Reactions.

The Journal of organic chemistry·2026
Same author

Bimetallic-Node-Occupied MOF With Glycoside Hydrolase Activity for Efficient Bacterial Biofilm Hydrolysis.

Angewandte Chemie (International ed. in English)·2026
Same author

Electrochemical and Hydrolytic Stability of Bidentate Alkyne-Based Self-Assembled Monolayers on Gold: Effect of Head and Foot Chain Lengths.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Molecular regulation and physiological role of GOLPH3-mediated Golgi retention.

Nature communications·2026
Same author

A Universal Poly(3,4-Ethylenedioxythiophene)-Based Hole Transport Layer Material for Efficient and Stable Organic Solar Cells.

ChemSusChem·2026
Same author

Solid Additives Promote Side-Chain Ordering and Molecular Packing To Enhance the Performance of Organic Solar Cells.

The journal of physical chemistry letters·2025

Related Experiment Video

Updated: Oct 21, 2025

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella
11:31

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella

Published on: November 30, 2018

7.6K

Ryanodine Receptor as Insecticide Target.

Arthur Samurkas1, Li Yao1, Hadiatullah Hadiatullah1

  • 1Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072,China.

Current Pharmaceutical Design
|September 3, 2021
PubMed
Summary

Diamide insecticides target insect ryanodine receptors (RyRs) to control pests. Mutations in insect RyRs are causing resistance, necessitating new insecticide designs based on RyR structure.

Keywords:
Ryanodine receptordiamideinsecticideresistancestructural biology.target

More Related Videos

Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects
10:14

Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects

Published on: May 4, 2018

14.0K
Electroporation-mediated RNA Interference Method in Odonata
13:28

Electroporation-mediated RNA Interference Method in Odonata

Published on: February 6, 2021

5.9K

Related Experiment Videos

Last Updated: Oct 21, 2025

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella
11:31

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella

Published on: November 30, 2018

7.6K
Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects
10:14

Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects

Published on: May 4, 2018

14.0K
Electroporation-mediated RNA Interference Method in Odonata
13:28

Electroporation-mediated RNA Interference Method in Odonata

Published on: February 6, 2021

5.9K

Area of Science:

  • Agricultural Entomology
  • Molecular Biology
  • Insecticide Development

Background:

  • Ryanodine receptors (RyRs) are key targets for diamide insecticides, crucial for managing agricultural pests.
  • Diamide insecticides exhibit high selectivity for lepidopteran and coleopteran pests, with low toxicity to non-target organisms.
  • Emerging resistance in major agricultural pests due to mutations in insect RyRs poses a significant challenge.

Purpose of the Study:

  • To review recent findings on insect RyR structure and function as insecticide targets.
  • To elucidate the molecular basis of insecticide action and selectivity by examining RyR structures.
  • To analyze structural and functional RyR changes associated with insecticide resistance.

Main Methods:

  • Comparative structural analysis of RyRs from target and non-target species.
  • Investigation of structural and functional alterations in RyRs due to resistance mutations.
  • Review of current progress in structure-based insecticide design.

Main Results:

  • Insect RyRs are the primary targets for diamide insecticides like flubendiamide and chlorantraniliprole.
  • RyR structure analysis reveals the molecular basis for diamide insecticide selectivity and efficacy.
  • Identified RyR mutations are responsible for insecticide resistance in key agricultural pests.

Conclusions:

  • Understanding insect RyR structure is critical for developing effective pest control strategies.
  • Structure-based design holds promise for creating next-generation, environmentally friendly insecticides.
  • Addressing RyR-mediated insecticide resistance is essential for sustainable agriculture.