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Updated: Oct 21, 2025

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
Published on: August 10, 2022
Refined transcriptional blueprint of human preimplantation embryos
Jere Weltner1, Fredrik Lanner2
1Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; Division of Obstetrics and Gynecology, Karolinska Universitetssjukhuset, Stockholm, Sweden.
Abstract:
Despite being a biologically fundamental question, the precise timing of lineage specification during human preimplantation development remains elusive. In this issue of Cell Stem Cell, Meistermann et al. (2021) refine our view through time-lapse embryo staging and single-cell sequencing and challenge the concept of a human inner cell mass.
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