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iChip

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The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

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Related Experiment Video

Updated: May 3, 2026

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Organs-on-a-chip models for biological research.

Gordana Vunjak-Novakovic¹, Kacey Ronaldson-Bouchard¹, Milica Radisic²

¹Columbia University, New York, NY, USA.

|September 3, 2021

Summary

Bioengineered human tissues, or organs-on-a-chip, offer advanced models for biological research. Future work will focus on validating and utilizing these complex, functional tissue systems.

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Last Updated: May 3, 2026

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

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Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

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Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Published on: February 17, 2023

Area of Science:

Biotechnology
Tissue Engineering
Physiological Modeling

Background:

Bioengineered human tissues, including organs-on-a-chip, are increasingly utilized in biological research.
These engineered tissues mimic native tissue phenotypes at molecular, structural, and functional levels.
Unlike spontaneously forming organoids, organs-on-a-chip are designed to replicate specific organ functions.

Purpose of the Study:

To explore the utility of bioengineered human tissues for biological research.
To review key developments in organs-on-a-chip technology.
To identify challenges in establishing, validating, and utilizing these models.

Main Methods:

Review of key developments in bioengineered tissue technology.
Analysis of the complexity and functionality of engineered tissues.
Discussion of challenges in model validation and application.

Main Results:

Engineered tissues, though smaller, approximate native tissue phenotypes.
Organs-on-a-chip are engineered for specific organ functions, differentiating them from organoids.
Key technological advancements have been made in this emerging field.

Conclusions:

Bioengineered human tissues represent a valuable tool for biological research.
Further efforts are needed to fully establish, validate, and utilize the fidelity of these models.
Addressing current challenges will enhance the application of organs-on-a-chip in scientific discovery.