EFFECT OF LOCALLY DELIVERED BISPHOSPHONATES ON ALVEOLAR BONE: A SYSTEMATIC REVIEW AND META-ANALYSIS

Area of Science:

• Periodontology and Dental Implantology
• Pharmacology and Regenerative Medicine

Background:

• Periodontitis often leads to alveolar bone defects, complicating dental implant placement and survival.
• Managing periodontal defects and ensuring bone stability around implants are critical for long-term success.

Purpose of the Study:

• To evaluate the efficacy of locally administered bisphosphonates in treating periodontal bone defects.
• To assess the impact of bisphosphonates on marginal bone levels following dental implant placement.

Main Methods:

• A systematic review and meta-analysis of randomized controlled clinical trials (2010-2020).
• Searched PubMed/MEDLINE, Web of Science, and Scopus databases.
• Assessed risk of bias and performed quantitative synthesis using fixed and random-effects models.

Main Results:

• Bisphosphonates significantly increased intrabony defect reduction in vertical defects and class II furcation defects compared to placebo.
• Local bisphosphonate application led to increased clinical attachment levels in treated periodontal defects.
• Dental implants coated with bisphosphonates showed significantly less marginal bone loss both pre- and post-loading.

Conclusions:

• Locally delivered bisphosphonates are effective in promoting bone regeneration within periodontal defects.
• Bisphosphonate therapy reduces marginal bone loss, improving bone stability around dental implants.
• This approach holds potential for enhancing treatment outcomes in periodontitis and implant dentistry.