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Updated: Oct 21, 2025

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes
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A Brain-Inspired Homeostatic Neuron Based on Phase-Change Memories for Efficient Neuromorphic Computing.

Irene Muñoz-Martin1, Stefano Bianchi1, Shahin Hashemkhani1

  • 1Dipartimento di Elettronica, Informazione e Bioingegneria (DEIB), Politecnico di Milano, Milan, Italy.

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Summary

This study introduces novel phase change memory (PCM) neurons for neuromorphic computing, enhancing learning robustness and energy efficiency in spiking neural networks (SNNs) through bio-inspired self-regulation and active forgetting.

Keywords:
brain-inspired computinghardware resiliencehomeostatic scalingphase change memoryreinforcement learningspike-timing-dependent plasticitysynaptic scalingunsupervised learning

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Area of Science:

  • Neuromorphic Engineering
  • Computational Neuroscience
  • Materials Science

Background:

  • Synaptic scaling is a biological homeostatic mechanism crucial for neural network learning.
  • Existing hardware spiking neural networks (SNNs) lack intrinsic dynamic regulation mechanisms.
  • Phase Change Memory (PCM) devices offer potential for novel artificial neuron designs.

Purpose of the Study:

  • To develop a novel artificial neuron using PCM devices for neuromorphic computing.
  • To implement homeostatic and plastic phenomena for internal regulation in SNNs.
  • To enhance learning capabilities, robustness, and energy efficiency in neuromorphic systems.

Main Methods:

  • Designed and fabricated novel PCM-based artificial neurons.
  • Integrated these neurons into spiking neural networks (SNNs).
  • Evaluated performance in multi-pattern learning, continual learning (CNNs), and autonomous navigation tasks.

Main Results:

  • Demonstrated increased robustness and optimized multi-pattern learning under spike-timing-dependent plasticity (STDP).
  • Improved continual learning resilience and accuracy in hybrid supervised-unsupervised convolutional neural networks (CNNs).
  • Showcased energy efficiency gains via bio-plausible active forgetting enabled by PCM conductance drift.

Conclusions:

  • PCM-based neurons enable self-regulating, dynamic SNNs with enhanced learning and robustness.
  • These neurons facilitate bio-inspired recurrent networks for autonomous decision-making.
  • PCM device characteristics, like conductance drift, can be leveraged for energy-efficient neuromorphic computing.