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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
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New insights in mite immunotherapy - sublingual tablets.
1Division of Allergy & Clinical Immunology, Johns Hopkins School of Medicine, Creticos Research Group, Crownsville, Maryland, USA.
Current Opinion in Allergy and Clinical Immunology
|September 8, 2021
Summary
Sublingual immunotherapy tablets (SLIT) effectively treat allergies from common allergens like dust mites. This approach offers a safer, convenient alternative for managing allergic rhinitis, conjunctivitis, and asthma in select patients.
Area of Science:
- Allergy and Immunology
- Immunotherapy
- Respiratory Medicine
Background:
- Sublingual tablet immunotherapy (SLIT) is effective for various allergies.
- House dust mite (HDM) allergy is a common cause of allergic rhinitis, conjunctivitis, and asthma.
Purpose of the Study:
- To review clinical studies on HDM SLIT-tablet for allergic rhinitis/conjunctivitis.
- To discuss the appropriate use of HDM SLIT-tablets in asthmatic patients.
- To provide practical management considerations for clinicians.
Main Methods:
- Evidence-based clinical studies were reviewed.
- Focus on studies addressing HDM SLIT-tablet efficacy and safety.
- Consideration of patient selection for immunotherapy.
Main Results:
- HDM SLIT-tablet is well-tolerated in mild-to-moderate asthma.
- Demonstrated improvements in asthma exacerbations and reduced need for rescue medication.
- Significant enhancements in quality of life and asthma control were observed.
Conclusions:
- HDM SLIT-tablet offers a safe and effective treatment option.
- Superior safety profile compared to subcutaneous immunotherapy.
- Facilitates management of persistent airway inflammation and allergic asthma.
