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Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide
Published on: December 19, 2020
Lipid phase dependent distinct emission behaviour of hydrophobic carbon dots: C-dot based membrane probes
Soumya Kanti De1, Avijit Maity1, Debanjan Bagchi1
1Department of Chemistry, Indian Institute of Technology Indore, Indore 453552, India. anjanc@iiti.ac.in.
Abstract:
We observe a unique distinct emission behaviour of hydrophobic carbon dots (H-CDs) embedded within the ordered and the disordered phase of a lipid membrane. The H-CDs exhibit blue emission in the disordered phase, however, they exhibit an intense red emission in the ordered phase of the lipid bilayer. The H-CDs have the potential ability to probe membrane dynamics like previously reported organic dyes. To the best of our knowledge, this is the first report of a CD-based membrane probe.

