RNA Dynamics in Alzheimer's Disease.

Area of Science:

• Neuroscience
• Molecular Biology
• Genetics

Background:

• Alzheimer's disease (AD) is a leading cause of age-related neurodegeneration, posing a significant global health challenge.
• The molecular underpinnings of AD remain incompletely understood, necessitating research into novel mechanisms.
• Transcriptome dysregulation and altered RNA binding protein (RBP) activity are emerging hallmarks of AD pathology.

Purpose of the Study:

• To provide a comprehensive review of altered RNA dynamics in Alzheimer's disease.
• To elucidate the role of RNA binding proteins (RBPs) in AD pathogenesis.
• To connect changes in RNA species abundance to AD pathology.

Main Methods:

• Literature review synthesizing current evidence on RNA alterations in AD.
• Analysis of studies investigating RBP expression and function in the context of AD.
• Examination of research linking specific RNA species (miRNAs, circRNAs, lncRNAs, mRNAs) to AD.

Main Results:

• AD is characterized by significant transcriptome dysregulation.
• Altered expression and function of RNA binding proteins (RBPs) are key features of AD.
• Changes in various RNA species, including microRNAs, circular RNAs, long non-coding RNAs, and messenger RNAs, are observed in AD.

Conclusions:

• Altered RNA dynamics and RBP dysfunction are central to Alzheimer's disease molecular pathology.
• Understanding these RNA-related changes offers potential therapeutic targets for AD.
• Further research into RNA species and RBP interactions is vital for advancing AD treatment strategies.