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Essential Minerals for Bone Health01:31

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
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Resorbable Mg2+-Containing Phosphates for Bone Tissue Repair.

Gilyana Kazakova1,2, Tatiana Safronova1,2, Daniil Golubchikov1

  • 1Department of Materials Science, Lomonosov Moscow State University, Laboratory Building B, 1-73 Leninskiye Gory, Moscow 119991, Russia.

Materials (Basel, Switzerland)
|September 10, 2021
PubMed
Summary

Magnesium phosphate biomaterials are crucial for bone tissue repair and regeneration. These materials support bone remodeling, osteosynthesis, and angiogenesis, enhancing bone reconstruction outcomes.

Keywords:
bioactivitybone reconstructioncalcium magnesium phosphatesnewberriteorthopedic applicationsresorbabilitystruvitewhitlockite

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Research

Background:

  • Magnesium (Mg2+)-containing phosphates are increasingly important for bone tissue repair.
  • Magnesium and phosphate ions are vital for bone remodeling and osteosynthesis.
  • Understanding these roles is key to advancing regenerative medicine.

Purpose of the Study:

  • To provide a comprehensive overview of magnesium phosphate and magnesium calcium phosphate biomaterials for bone reconstruction.
  • To explore the role of magnesium ions in angiogenesis and osteogenesis.
  • To summarize the biological properties of calcium magnesium phosphates in bone regeneration.

Main Methods:

  • Literature review of studies on magnesium phosphate biomaterials.
  • Analysis of the role of magnesium in angiogenesis and osteogenesis.
  • Synthesis of biological properties data for calcium magnesium phosphates.

Main Results:

  • Magnesium phosphate and magnesium calcium phosphate biomaterials show significant promise in bone reconstruction.
  • Magnesium ions actively participate in osteosynthesis and promote angiogenesis.
  • Calcium magnesium phosphates exhibit beneficial biological properties for bone regeneration.

Conclusions:

  • Magnesium-based phosphates are highly relevant for bone tissue engineering and regenerative medicine.
  • These materials effectively support critical biological processes like osteogenesis and angiogenesis.
  • Further research into calcium magnesium phosphates can lead to improved bone regeneration strategies.