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Microbiome and cancer.

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The human microbiome influences cancer development and treatment. Understanding these interactions offers potential for novel precision cancer therapies targeting microbes or their metabolites.

Keywords:
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Area of Science:

  • Microbiology
  • Oncology
  • Immunology

Background:

  • The human microbiome is a complex community of microorganisms interacting with the host.
  • Host-microbiome interactions affect physiological processes and disease, including cancer.
  • Emerging evidence suggests the microbiome influences cancer development, progression, metastasis, and treatment response.

Purpose of the Study:

  • To review the molecular mechanisms by which the microbiome contributes to cancer initiation and progression.
  • To highlight advances and challenges in understanding microbiome-cancer causal links.
  • To explore the potential of targeting the microbiome for precision cancer therapeutics.

Main Methods:

  • Literature review of studies investigating microbial roles in cancer.
  • Analysis of molecular pathogenic mechanisms shared across microbial niches.
  • Synthesis of current knowledge on microbiome-host-cancer interactions.

Main Results:

  • Microbial factors contribute to cancer initiation and progression through shared molecular pathways.
  • The microbiome impacts cancer treatment responsiveness.
  • Microorganisms and their metabolites show promise as therapeutic targets.

Conclusions:

  • Enhanced molecular understanding of microbiome-cancer interactions is crucial for clinical relevance.
  • Targeting the microbiome offers a promising avenue for developing precision cancer therapies.
  • Further research is needed to fully unravel causal links and therapeutic potential.