Related Experiment Videos
[Reference values for sialic acid in the urine]
R Grisler1, C Giavardi, R Scaricabarozzi
1Laboratorio di ricerche cliniche, anatomia ed istologia patolgica, Istituti Clinici di Perfezionamento, Milano.
Quaderni Sclavo Di Diagnostica Clinica E Di Laboratorio
|June 1, 1987
Summary
Urinary sialic acid levels were measured in 250 individuals. After removing inhibitors, mean values were determined, providing a baseline for this biomarker in normal renal function.
Area of Science:
- Biochemistry
- Clinical Chemistry
- Urology
Context:
- Sialic acid is a key component of glycoproteins and glycolipids.
- Accurate measurement of urinary sialic acid is important for understanding metabolic processes.
- This study focused on individuals with normal urine analysis, serum urea, glucose, and creatinine clearance.
Purpose:
- To evaluate and establish reference ranges for urinary sialic acid levels.
- To assess the impact of charcoal treatment on pyruvate-oxidase inhibitor removal for accurate sialic acid quantification.
- To provide baseline data for urinary sialic acid in a healthy population.
Summary:
- Urinary sialic acid was measured using an enzymatic colorimetric method in 250 healthy males and females.
- Samples were treated with activated charcoal to eliminate pyruvate-oxidase inhibitors.
- Mean urinary sialic acid values were determined as 53.4 mg/L, 63.5 mg/24 hours, and 58.7 mg/24 hours/1.73 m².
Impact:
- Establishes reference values for urinary sialic acid in a healthy cohort.
- Highlights the importance of inhibitor removal for accurate biochemical analysis.
- Provides a foundation for future research into sialic acid's role in various physiological and pathological conditions.