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[Reference values for sialic acid in the urine].

R Grisler1, C Giavardi, R Scaricabarozzi

  • 1Laboratorio di ricerche cliniche, anatomia ed istologia patolgica, Istituti Clinici di Perfezionamento, Milano.

Quaderni Sclavo Di Diagnostica Clinica E Di Laboratorio
|June 1, 1987
PubMed
Summary
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Urinary sialic acid levels were measured in 250 individuals. After removing inhibitors, mean values were determined, providing a baseline for this biomarker in normal renal function.

Area of Science:

  • Biochemistry
  • Clinical Chemistry
  • Urology

Context:

  • Sialic acid is a key component of glycoproteins and glycolipids.
  • Accurate measurement of urinary sialic acid is important for understanding metabolic processes.
  • This study focused on individuals with normal urine analysis, serum urea, glucose, and creatinine clearance.

Purpose:

  • To evaluate and establish reference ranges for urinary sialic acid levels.
  • To assess the impact of charcoal treatment on pyruvate-oxidase inhibitor removal for accurate sialic acid quantification.
  • To provide baseline data for urinary sialic acid in a healthy population.

Summary:

  • Urinary sialic acid was measured using an enzymatic colorimetric method in 250 healthy males and females.
  • Samples were treated with activated charcoal to eliminate pyruvate-oxidase inhibitors.

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  • Mean urinary sialic acid values were determined as 53.4 mg/L, 63.5 mg/24 hours, and 58.7 mg/24 hours/1.73 m².

    • Impact:

    • Establishes reference values for urinary sialic acid in a healthy cohort.
    • Highlights the importance of inhibitor removal for accurate biochemical analysis.
    • Provides a foundation for future research into sialic acid's role in various physiological and pathological conditions.