Sugarcane Workweek Study: Risk Factors for Daily Changes in Creatinine.
Jaime Butler-Dawson1,2, Lyndsay Krisher1,2, Miranda Dally1,2
1Center for Health, Work, & Environment, Colorado School of Public Health, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Kidney International Reports
|September 13, 2021
Summary
High heat and blood pressure increase kidney strain in agricultural workers. Protective measures include rest breaks and safe water sources, reducing kidney injury risk.
Area of Science:
- Environmental Health
- Occupational Medicine
- Nephrology
Background:
- Agricultural workers face elevated kidney injury risk due to heat stress and occupational exposures.
- Chronic kidney disease of unknown origin (CKDu) is a concern in thermally stressful environments.
- This study investigates kidney stress in Guatemalan sugarcane workers during a typical workweek.
Purpose of the Study:
- To examine the effects of occupational, environmental, and lifestyle factors on kidney stress in agricultural workers.
- To identify risk factors and protective measures for kidney injury in this population.
- To understand the impact of simultaneous work and environmental strains on kidney function.
Main Methods:
- Data collected from 107 sugarcane workers over 7 consecutive work shifts.
- Included daily occupational, meteorological, environmental, and lifestyle factors.
- Multivariable linear mixed models assessed associations with percent change in creatinine.
Main Results:
- Increased wet bulb globe temperature and diastolic blood pressure correlated with higher creatinine levels.
- Rest breaks and consumption of chlorinated tank water were protective against creatinine increases.
- Tank water drinkers showed lower urine concentrations of arsenic, lead, uranium, and glyphosate.
Conclusions:
- Preventive strategies are crucial for reducing kidney injury in agricultural workers.
- Key interventions include reducing heat stress and managing blood pressure.
- Investigating water sources for nephrotoxic contaminants is essential.
More Related Videos
Related Concept Videos
01:25Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
32
In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
32
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
31
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
31
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
90
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
90
01:17Factors Affecting Renal Clearance: Renal Impairment
207
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
207
01:24Chronic Kidney Disease II: Clinical Manifestations
171
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
171
01:25Chronic Kidney Disease I: Introduction
220
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
220