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Peptide Bonds

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...

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Related Experiment Video

Updated: Oct 20, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Peptide-Based Supramolecular Systems Chemistry.

Fahmeed Sheehan^1,2,3, Deborah Sementa¹, Ankit Jain¹

¹Advanced Science Research Center (ASRC) at the Graduate Center City University of New York 85 St. Nicholas Terrace New York, New York 10031, United States.

Chemical Reviews

|September 14, 2021

Summary

This summary is machine-generated.

Peptide supramolecular systems chemistry advances by integrating multiple reactions for complex functions. This research focuses on designing adaptive materials with tunable photonic, electronic, and catalytic properties.

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Last Updated: Oct 20, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

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Published on: November 21, 2013

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

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Published on: February 6, 2020

Area of Science:

Supramolecular Chemistry
Materials Science
Chemical Biology

Background:

Life uses conserved building blocks and reactions for diverse functions.
Peptide-based nanomaterials demonstrate self-assembly, recognition, catalysis, and actuation.
Current research is moving towards systems-level design for coordinated functions.

Purpose of the Study:

To explore systems-level design principles in peptide-based supramolecular chemistry.
To develop adaptive materials with tunable properties.
To integrate multiple chemical reactions and interactions for complex functions.

Main Methods:

Discussing key features for systems-level design.
Incorporating kinetic and thermodynamic design aspects.
Utilizing combinatorial dynamic covalent and noncovalent interactions.

Main Results:

Regulating supramolecular order and disorder is crucial.
Active and adaptive systems can be developed through careful design.
Structural and dynamic design concepts like preorganization and induced fit are critical.

Conclusions:

Integrated peptide supramolecular systems enable adaptive materials.
Tunable photonic, electronic, and catalytic properties are achievable.
Combined features lead to emergent adaptive properties not possible with single components.